Updated: September, 2025

Best cold medicines

Save up to 26% Off

1

Vicks

9.8

Exceptional

VICKS DayQuil & NyQuil SEVERE Honey Flavor Co-Pack, Cold & Flu Medicine, Relieves Headache, Fever, Sore Throat, Minor Aches & Pains, Nasal Congestion, Sinus Pressure, Stuffy Nose, and Cough, 2x12oz

10% Off

Why we love it

Effective relief for cold and flu symptoms.

Honey flavor improves taste experience.

Day and night formulas for 24-hour relief.

Main highlights

Maximum Strength Relief
Provides powerful relief for 9 cold and flu symptoms with real honey flavor.

Day and Night Use
Ideal for treating symptoms any time with non-drowsy DayQuil and restful NyQuil.

Honey Flavor Praised
Most users appreciate the honey flavor for better taste compared to traditional options.

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Careful review Our team ensures quality, value, and fit based on real user feedback

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Real users impact

Thousands of users trust our site daily

Based on millions of stores and reviews

Shoppers influence our rankings
Analyzing top stores
How do we rank?

Using our advanced technology, we scan thousands of products and stores, analyzing reviews, ratings, and trends to find what matters most to users like you.

Our team then reviews the data and real user feedback, combining AI and human insights to bring you real-time, top-rated recommendations to guide your decisions with clarity and confidence.
2

Vicks

9.7

Exceptional

Vicks DayQuil and NyQuil Combo Pack, Cold & Flu Medicine, Powerful Multi-Symptom Daytime And Nighttime Relief For Headache, Fever, Sore Throat, Cough, 24 Count, 16 DayQuil, 8 NyQuil Liquicaps

Why we love it

Fast relief

Powerful multi symptom relief

Non drowsy relief

Main highlights

Key Features
Offers fast, powerful relief for both day and night, targeting multiple cold and flu symptoms with non-drowsy DayQuil and NyQuil formulas.

Ideal Use Cases
Best used when needing to maintain daytime activity without drowsiness and achieving restful sleep at night despite cold and flu symptoms.

Customer Praise
Most reviews highlight the fast-acting relief and effectiveness in alleviating a wide range of symptoms, appreciating the day and night support.

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3

Tylenol

9.6

Exceptional

Tylenol Cold + Flu Severe Day & Night Caplets for Fever, Pain, Cough & Congestion Relief, 24 Count

15% Off

Why we love it

Comprehensive multi-symptom relief.

Day and night formulas included.

Highly recommended for Tylenol users.

Main highlights

Comprehensive Cold Flu Relief
24-count pack offers multi-symptom relief for cold and flu.

Day Night Usage
Ideal for day and night relief with separate formulas.

Highly Praised Value
Customers appreciate the value and effectiveness of the product.

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4

Mucinex

9.5

Excellent

Mucinex Fast-Max Liquid Gels for Day/Night Cold and Flu, 24 Count

26% Off

Why we love it

Fast relief from multiple symptoms.

Day and night formulas included.

Highly trusted brand.

Main highlights

Multi-Symptom Relief Efficiency
Provides fast, powerful relief for 9 cold and flu symptoms.

Ideal for Day and Night Use
Designed for comprehensive symptom management, both day and night.

Quick Symptom Relief Praised
Customers appreciate the fast-acting relief, often within two doses.

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5

Amazon Basic Care

9.4

Excellent

Amazon Basic Care Cold and Flu Relief, Daytime and Nighttime Combo Pack Softgels, Powerful Cold Medicine for Day and Night Multi-Symptom Relief, 48 Count(Pack of 1)

Why we love it

Effective against cold and flu symptoms.

Affordable price for quality medicine.

Convenient day and night dosing.

Main highlights

Multi-Symptom Relief
Provides effective relief from headache, fever, sore throat, and more.

Day and Night Use
Ideal for continuous relief of cold and flu symptoms.

Quick Action
Praised for fast-acting relief within a few hours.

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6

Tylenol

9.3

Excellent

Tylenol Cold + Head Congestion Severe Medicine Caplets for Fever, Pain, and Congestion, Acetaminophen Pain Reliever, Fever Reducer, 24 Count

Why we love it

Effective multi-symptom relief.

Trusted brand for pain relief.

Clears congestion effectively.

Main highlights

Comprehensive Relief
24-count caplets relieve headache, congestion, sore throat, and fever.

Ideal for Cold and Flu
Best for adults and children 12+ with severe symptoms.

Customer Praised Clarity
Highly rated for keeping head clear and improving breathing.

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7

Coricidin HBP

9.2

Excellent

Coricidin HBP Decongestant-Free Cough and Cold Medicine - Specially Designed Relief for High Blood Pressure, Cough, Runny Nose, Sneezing and Cold Symptoms (16 Count)

Why we love it

Safe for high blood pressure patients.

Effective against multiple cold symptoms.

Quick relief and enhances sleep quality.

Main highlights

Powerful Cold Relief for High Blood Pressure
Specially formulated to relieve cold symptoms without affecting blood pressure.

Ideal for Adults with Cold Symptoms
Targets cough, runny nose, and sneezing, perfect for cold relief.

Praised for Fast and Effective Relief
Customers appreciate its ability to provide quick symptom relief and improve sleep.

More info
8

Amazon Basic Care

9.1

Excellent

Amazon Basic Care Daytime Severe Cold & Flu Relief Caplets, Medication for Severe Cold and Flu Symptoms Like Headache, Fever, Coughing, Chest & Nasal Congestion, Vapor Ice, 24 Count

Why we love it

Multi symptom relief

Pain fever reducer

Cough phlegm relief

Main highlights

Key Features
Combines acetaminophen, dextromethorphan, guaifenesin, phenylephrine for comprehensive cold, flu relief. Compares to Vicks DayQuil Severe+ VapoCOOL.

Ideal Use Cases
Effective for daytime relief of severe cold and flu symptoms, including fever, headache, cough, and nasal congestion.

Customer Praise
Users frequently highlight its effectiveness in relieving a wide range of symptoms quickly, appreciating the fast-acting formula.

More info
9

Amazon Basic Care

9.0

Excellent

Amazon Basic Care Severe Daytime Cold and Flu, Maximum Strength Liquid Cold Medicine, Non-Drowsy, Multi-Symptom Relief, for Adults and Children Age 6 and Over, Original, 12 fl oz (Pack of 1)

Why we love it

Relieves multiple cold and flu symptoms effectively.

Non-drowsy formula for daytime use.

Contains maximum-strength active ingredients.

Main highlights

Multi-Symptom Relief for Cold and Flu
Combines pain reliever, cough suppressant, expectorant, and decongestant for comprehensive relief.

Ideal for Daytime Use
Non-drowsy formula allows users to maintain daily activities while managing symptoms.

Comparable to Name Brand
Customers praise its effectiveness and similarity to name brand counterparts.

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10

HealthA2Z

8.7

Very Good

HealthA2Z® Daytime and Nighttime | Cold & Flu Medicine | Powerful Multi-Symptom Daytime and Nighttime Relief (24 Daytime & 12 Nighttime Softgels) (Daytime & Nighttime Combo (36 Count Pack of 1))

Why we love it

Affordable alternative to name brands.

Includes both day and night relief.

Easy-to-swallow softgels.

Main highlights

Powerful Multi-Symptom Relief
HealthA2Z Daytime and Nighttime Cold & Flu Medicine offers effective relief for various symptoms, similar to leading brands, at a great value.

Convenient Day and Night Use
Includes both daytime and nighttime formulas in one package, perfect for around-the-clock symptom management.

Easy to Swallow Softgels
Customers appreciate the easy-to-swallow softgel capsules with no aftertaste, enhancing user experience.

More info

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Our top pick

1
10% Off

VICKS DayQuil & NyQuil SEVERE Honey Flavor Co-Pack, Cold & Flu Medicine, Relieves Headache, Fever, Sore Throat, Minor Aches & Pains, Nasal Congestion, Sinus Pressure, Stuffy Nose, and Cough, 2x12oz
The Vicks DayQuil & NyQuil Severe Combo Pack offers maximum strength relief for cold and flu symptoms with a unique honey flavor. This pack includes both DayQuil and NyQuil formulations, providing effective symptom management around the clock. DayQuil is non-drowsy, making it perfect for daytime use, while NyQuil aids in restful sleep at night. The honey flavor is a standout feature, appreciated by many users for its improved taste over traditional flavors. This product is ideal for those seeking comprehensive symptom relief with the added benefit of a more palatable experience. Whether dealing with a sore throat, fever, or congestion, this combo pack is designed to tackle multiple symptoms effectively, ensuring you can continue your daily activities or get a good night's rest.

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