Updated: July, 2025

Best overnight eye drops

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1

TheraTears

9.9

Exceptional

TheraTears Liquid Gel Nighttime Eye Drops for Dry Eyes, 30 Vials, 30 Count (Pack of 2)

Why we love it

Soothes dry eyes overnight.

Preservative-free for sensitive eyes.

Doctor recommended and researched.

Main highlights

Silky Hydration for Dry Eyes
TheraTears Liquid Gel provides soothing overnight relief and protection for dry eyes with its unique silky hydration formula.

Ideal for Nighttime Use
Perfect for overnight relief, these eye drops protect and soothe dry eyes while you sleep.

Doctor Developed and Recommended
Praised for being developed by an ophthalmologist after 18 years of research, ensuring effectiveness and safety.

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How do we rank?

How do we rank
Our AI-powered platform ranks products using multiple weighted factors from millions of products and user reviews across the web, providing the most valuable and real data. Higher scores rank first.
2

TheraTears

9.7

Exceptional

TheraTears Liquid Gel Nighttime Lubricating Eye Drops for Dry Eyes, Single-Use Vials, 30 Count

Why we love it

The product provides soothing relief for dry eyes overnight

The product contains 5 vital electrolytes found in natural tears

The product is preservative free and comes in single use vials

Main highlights

Key Features
Soothing overnight relief for dry eyes with 5 vital electrolytes, mimicking natural tears. Preservative-free, doctor-recommended, and created after 18 years of research.

Ideal Use Cases
Perfect for nighttime use, offering intensive hydration for sensitive eyes suffering from dryness, correcting salt imbalance for overnight comfort.

Customer Reviews
Most praised for its effective relief and noticeable improvement in dry eye symptoms, offering a silky, non-irritating formula in convenient single-use vials.

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3

Systane

9.5

Excellent

Systane Nighttime Lubricant Eye Ointment 3.5g Tube

Why we love it

Provides long-lasting eye protection.

Ideal for nighttime use.

Highly soothing for dry eyes.

Main highlights

Long-Lasting Protection
Forms a long-lasting, protective layer on eyes while you sleep, soothing and protecting against dryness and irritation.

Ideal for Nighttime Use
Best used for nighttime relief of dry eye symptoms, providing comfort and protection as you rest.

Soothing Effect
Most praised for its soothing effect, alleviating discomfort from dry eyes effectively.

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4

Clear Eyes

9.3

Excellent

Clear Eyes Nighttime Restoring Eyes Drops, Nighttime Relief Dry Eye Drops, 0.5 Fl Oz

Why we love it

Gentle, non-blurring formula.

Effective overnight relief.

Long-lasting hydration.

Main highlights

Hydrating Relief Without Blurring
Clear Eyes Nighttime Restoring Eye Drops provide soothing relief without the blurriness of gels or ointments.

Ideal for Nighttime Use
Perfect for use before bed to ensure refreshed eyes by morning.

Long-Lasting Moisture
Customers praise the drops for lasting moisture throughout the night.

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5

iVIZIA

9.1

Excellent

iVIZIA Lubricant Eye Gel for Severe and Nighttime Dry Eye Relief, Preservative-Free, Moisturizing, 30 Sterile Single-Use Vials Packaging May Vary

Why we love it

Thicker formula provides extended moisture overnight.

Preservative-free, suitable for post-surgery use.

Single-use vials ensure convenience and sterility.

Main highlights

Thicker Formula for Overnight Use
The gel provides more lubrication and moisture than daytime formulas, ideal for relieving severe dry eye symptoms, especially overnight.

Ideal for Severe Dry Eye or Nighttime Use
iVIZIA Lubricant Eye Gel is perfect for individuals with severe dry eye symptoms or those needing extra moisture during nighttime.

Long-Lasting Hydration
Customers frequently praise the product for its ability to provide lasting relief and hydration, reducing the need for frequent reapplication.

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6

Soothe

8.9

Very Good

Soothe Preservative-Free Lubricant Eye Ointment, Nighttime Relief for Severe Dry & Irritated Eyes, Gentle for Sensitive Eyes, 0.12 Fl Oz

Why we love it

Instant relief

No preservatives

Gentle use

Main highlights

Key Features and Benefits
Moisturizes and refreshes severe dry eyes overnight with a soothing formula, containing two lubricants for long-lasting relief and comfort.

Ideal Use Cases
Perfect for individuals suffering from severe dry eyes, especially effective overnight to prevent irritation and provide relief from dryness.

Customer Reviews Highlight
Most reviews praise its effectiveness in providing significant relief from severe dryness, noting its ease of use and overnight comfort.

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7

LUMIFY

8.7

Very Good

LUMIFY Eye Drops for Red Eyes, Redness Reliever for Brighter Looking Eyes, Works in 1 Minute & Lasts Up to 8 Hours, Eye Drops, 0.25 Fl Oz (7.5mL)

Why we love it

Works in just one minute.

Brightens and whitens eye appearance.

Long-lasting redness relief.

Main highlights

Redness Relief and Radiance
LUMIFY eye drops reduce redness to reveal natural radiance, working in 1 minute and lasting up to 8 hours.

Ideal for Quick Redness Fix
Perfect for sporadic redness relief and enhancing appearance for events or photo shoots.

Praised for Brightening Effect
Customers love LUMIFY for its ability to brighten eye whites and improve appearance instantly.

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8

LUMIFY

8.6

Very Good

LUMIFY Eye Drops for Red Eyes, Redness Reliever for Brighter Looking Eyes, Works in 1 Minute & Lasts Up to 8 Hours, Eye Drops, 0.08 Fl Oz (2.5 mL)

Why we love it

Reduces eye redness quickly.

No burning or itching.

Compact and travel-friendly.

Main highlights

Fast-Acting Redness Relief
LUMIFY reduces eye redness in 1 minute, lasting up to 8 hours.

Ideal for Allergy-Prone Eyes
Perfect for those with allergies causing chronic red eyes.

Highly Praised Whitening Effect
Customers love the noticeable whitening effect on their eyes.

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9

Systane

8.3

Good

Systane Lubricant Eye Gel Drops, 10-mL (Packaging May Vary)

20% Off

Why we love it

Provides long-lasting eye moisture.

Ideal for nighttime use.

Highly recommended by users.

Main highlights

Long-Lasting Relief
Thicker formulation offers prolonged relief from dry eye discomfort.

Ideal for Night Use
Perfect for overnight use due to gel-like consistency.

Highly Praised Moisturization
Customers love the effective moisturization that lasts through the night.

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10

Refresh

8.2

Good

Refresh Optive Gel Drops Lubricant Eye Gel For Dry Eyes, 0.33 Oz Sterile

20% Off

Why we love it

Provides long-lasting eye moisture.

Ideal for nighttime use.

Highly recommended for dry eyes.

Main highlights

Extended Relief and Protection
Offers comprehensive gel formula for dry, irritated eyes with lasting comfort.

Best for Nighttime Use
Perfect for nighttime application to relieve eye irritation and maintain moisture.

Highly Praised for Effectiveness
Customers appreciate its superior performance in moisturizing extremely dry eyes.

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Our top pick

1

TheraTears Liquid Gel Nighttime Eye Drops for Dry Eyes, 30 Vials, 30 Count (Pack of 2)
TheraTears Liquid Gel Nighttime Eye Drops are designed to provide soothing overnight relief for dry eyes. With a unique silky hydration formula, these drops offer protection and comfort while you sleep, making them ideal for nighttime use. Developed by an ophthalmologist after 18 years of research, TheraTears is a trusted choice for those seeking effective dry eye relief. The product is preservative-free, catering to sensitive eyes, and comes in single-use vials to ensure freshness. Additionally, it is FSA- and HSA-eligible in the U.S., adding to its practicality. Whether you're dealing with chronic dry eye symptoms or occasional discomfort, TheraTears offers a reliable solution that is both doctor-recommended and widely praised by users for its effectiveness and gentle formula.

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